Memory Disorders Clinical Trials

Stanford Clinical Trials

The PLasma for Alzheimer's SymptoM Amelioration (PLASMA) Study

A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial of Intravenously Administered Plasma from Young Donors for Treatment of Mild-to-Moderate Alzheimer's Disease
Details: The PLASMA study is a clinical trial for patients with mild, moderate, or severe Alzheimer's disease and involves weekly infusions of "young blood". The study is based on the work of Stanford scientists who found that plasma from young human donors had rejuvenating benefits when injected into old mice. This research is now being tested in human patients to test the safety and tolerability of weekly plasma infusions in people with Alzheimer's disease. Patients who are eligible to enroll in the study will receive monthly neurological and physical exams along with Neuropsychological testing and brain imaging over a 4 month span. A reliable study partner or caregiver is required to participate in the study and will be asked to accompany the patient to their visits as well to provide feedback on the patients daily functioning. If your interested in participating in the PLASMA trial please contact Ethan Solomon at 650-850-1853 to setup an initial screening visit. (Medical records and previous brain imaging results from outside providers may be requested prior to study enrollment to determine study eligibility). 
Status: Active, Enrolling
PI: Sharon J. Sha, MD MS (NCT02256306)
Research coordinator: Ethan Solomon
esolo@stanford.edu, 650-850-1853

Efficacy and Safety Trial of MK-8931 in Participants with Prodromal Alzheimer's Disease

A Phase III, Randomized, Placebo-Controlled, Parallel-Group, Double-Blind Clinical Trial to Study the Efficacy and Safety of MK-8931 in Subjects with Amnestic Mild Cognitive Impairment Due to Alzheimer’s Disease.
Status: Active, Enrolling
PI: Sharon J. Sha, MD MS (NCT01953601)
Clinical Research Coordinator: Tatiana Marcal
tmarcal@stanford.edu, (650) 723-3657

The Aging Brain Study

This is a longitudinal study enrolling individuals with Alzheimer’s disease, Mild Cognitive Impairment, Lewy Body Dementia, Parkinson’s disease, Parkinson’s disease with dementia and healthy volunteers. It is funded by the National Institute of Health and is part of the Alzheimer’s Disease Research Center (ADRC). This study will collect data including medical history, family history and medication. There will be questionnaires to be filled out, cognitive testing and MRI of the brain. This study will follow participants over time.
Status: active, enrolling
PI: Victor Henderson, MD
CO-PI: Tony Wyss-Coray, PhD

High Resolution Imaging of Hippocampal Mechanisms in Age-Related Memory Decline

This study will enroll healthy older adults without memory complaints to better understand the processes and mechanisms of memory that change as we age.
Status: Active, Enrolling
PI:  Anthony Wagner, PhD
Research coordinator: Jeffrey Bernstein
jdberns@stanford.edu, (650) 723-8999

Multiple Dose Study of BIIB037 (Recombinant, Fully Human Anti-Aβ IgG1 mAb) in Participants With Prodromal or Mild Alzheimer's Disease

A Randomized, Double-Blinded, Placebo-Controlled Multiple Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB037 in Subjects With Prodromal or Mild Alzheimer's Disease
Status: Ongoing, Closed
PI: Sharon J. Sha, MD MS (NCT01677572)
Clinical Research Coordinator: Tatiana Marcal
tmarcal@stanford.edu, (650) 723-3657

Long-Term Safety Extension Study of Studies ABE4869g and ABE4955g in Patients with Mild to Moderate Alzheimer's Disease Treated with Crenezumab

A Multicenter, Open-Label, Long-Term Safety Extension Of Phase II Studies ABE4869g And ABE4955g In Patients With Mild To Moderate Alzheimer's Disease
Status: Ongoing, Closed
PI: Sharon J. Sha, MD MS (NCT01723826)
Clinical Research Coordinator: Tatiana Marcal
tmarcal@stanford.edu, (650) 723-3657

Structural Correlates of Cognitive and Motor Dysfunction in Parkinsonian Disorders

Status: Open, enrollment ongoing
PI: Kathleen Poston, MD, MS
Research coordinator: Anisa Marshall
anisa@stanford.edu, (650) 723-0060

Stanford Brain Bank Program

This study seeks a broad range of participants with neurological disorders, including Alzheimer’s disease, Parkinson’s disease, Lewy Body Disease, and other disorders of the brain.  We also seek healthy older adults age 65 and older without a brain disorder to serve as controls.   Participants will be asked to consider brain donation at the time of death.  Autopsy tissues will be used to help our scientists better understand neurodegenerative disorders and other brain diseases, by comparing clinical and autopsy findings and by examining microscopic, biochemical and genetic features.  The pathologist’s brain autopsy report will be provided to family members. 
Status: Open, enrollment ongoing, limited to current or past Stanford Health Care patients.
PI: Victor Henderson, MD, MS, Co-PI: Edward Plowey, MD, PhD
Research coordinator: Christina Wyss-Coray, RN
cwysscoray@stanfordhealthcare.org, (650) 721 2409

Clinical trials contacts

Tatiana Marcal
Clinical Research Coordinator
650-723-3657
tmarcal@stanford.edu

Sharon Sha, MD, MS
Clinical Assistant Professor, Neurology & Neurological Sciences
Director, Memory Disorders Clinical Trials
ssha1@stanford.edu
(650) 723-5072