Our Pioneering Research

Our Center brings together top-ranked scientists, physician-scientists, clinical caregivers and specialists, as well as world-class research teams with the goals of making long lasting changes in the field of allergy research and developing a cure for allergies.

Laboratory Research

Advancing the scientific understanding of immune disorders and allergies through innovative research. We have discovered new treatments and more accurate diagnostic and predictive tests.

Read about new blood tests

Computational Biology Research

Collaborating to create and leverage a database of research findings from leading, like-minded institutions around the world.

Clinical Trials

Translating research discoveries in immunology into treatments for patients around the world. We aim to provide long-lasting, safe, individualized treatments for patients of all ages. Learn more.

Access to our groundbreaking research findings and tests are available to all sites and patients within our worldwide alliance.

We use our innovative measurement tools and scientific knowledge in immunology and genetics to discover the cause of allergies and develop strategies to prevent them.

Recent Peer-Reviewed Research Publications

2015 Publications

Bégin P, Nadeau KC. Changes in peanut-specific T-cell clonotype with oral immunotherapy. J Allergy Clin Immunol. 2015 Apr 27 [epub ahead of print].
Mathieu AL, Verronese E, Rice GI, Fouyssac F, Bertrand Y, Picard C, Chansel M, Walter JE, Notarangelo LD, Butte MJ, Nadeau KC, Csomos K, Chen DJ, Chen K, Delgado A, Rigal C, Bardin C, Schuetz C, Moshous D, Reumaux H, Plenat F, Phan A, Zabot MT, Balme B, Viel S, Bienvenu J, Cochat P, van der Burg M, Caux C, Kemp EH, Rouvet I, Malcus C, Méritet JF, Lim A, Crow YJ, Fabien N, Ménétrier-Caux C, De Villartay JP, Walzer T, Belot A. PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity. J Allergy Clin Immunol. 2015 Apr 1; S0091-6749(15)00185-2.
Hong X, Hao K, Ladd-Acosta C, Hansen KD, Tsai HJ, Liu X, Xu X, Thornton TA, Caruso D, Keet CA, Sun Y, Wang G, Luo W, Kumar R, Fuleihan R, Singh AM, Kim JS, Story RE, Gupta RS, Gao P, Chen Z, Walker SO, Bartell TR, Beaty TH, Fallin MD, Schleimer R, Holt PG, Nadeau KC, Wood RA, Pongracic JA, Weeks DE, Wang X. Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. Nat Commun. 2015 Feb 24;6:6304.
Bauer RN, Manohar M, Singh AM, Jay DC, Nadeau KC. The future of biologics: Applications for food allergy. J Allergy Clin Immunol. 2015 Feb;135(2):312-323.
Pajno GB, Nadeau KC, Passalacqua G, Caminiti L, Hobson B, Jay DC, Arasi S, Chiera F, Salzano G. The evolution of allergen and non-specific immunotherapy: past achievements, current applications and future outlook. Expert Rev Clin Immunol. 2015 Jan;11(1):141-54.
Hew KM, Walker AI, Kohli A, Garcia M, Syed A, McDonald-Hyman C, Noth B, Mann J, Pratt B, Balmes J, Hammond K, Eisen E, Nadeau KC. Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells. Clin Exp Allergy. 2015 Jan;45(1):238-48.

2014 Publications

Sleiman P, Wang ML, Cianferoni A, Aceves S, Gonsalves N, Nadeau KC, Bredenoord A, Furuta G, Spergel J, and Hakonarson H. GWAS identifies four novel eosinophilic esophagitis loci. Nature Communications. 2014 Nov 19;5:5593. *Participated in enrolling patients, provided technical support and material support.
Arasi S, Klingbeil E, Dominguez T, and Nadeau KC. Two year long term data on Quality of Life in Multiple Food Allergy Oral Immunotherapy. Allergy, Asthma, and Clinical Immunology. 2014 Nov; 10:57
Jay D, Manohar M, and Nadeau KC. Immune Mechanisms of Sublingual Immunotherapy. Current Allergy and Asthma Reports. 2014 Nov;14(11):473.
Lv N, Xiao L, Camargo C, Wilson S, Buist S, Strub P, Nadeau K, and Ma J. Abdominal and General Adiposity and Level of Asthma Control in Adults with Uncontrolled Asthma. Annals of the American Thoracic Society. 2014 Oct;11(8):1218-24. *Participated in acquisition of data, technical support, material support, and analysis and interpretation of data.
Rothenberg ME, Wen T, Greenberg A, Alpan O, Enav B, Hirano I, Nadeau KC, Kaiser S, Peters T, Perez A, Jones I, Arm JP, Strieter RM, Sabo R, Gunawardena KA. Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis. J Allergy Clin Immunol. 2014 Sep 13. *Participated in enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Alexander ES, Martin LJ, Collins MH, Kottyan LC, Sucharew H, He H, Mukkada VA, Succop PA, Abonia JP, Foote H, Eby MD, Grotjan TM, Greenler AJ, Dellon ES, Demain JG, Furuta GT, Gurian LE, Harley JB, Hopp RJ, Kagalwalla A, Kaul A, Nadeau KC, Noel RJ, Putnam PE, von Tiehl KF, Rothenberg ME. Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis. J Allergy Clin Immunol. 2014 Sep 1. *Participated in enrolling patients in the study and acquisition of data.
Sampson H, Aceves S, Bock A, James J, Jones S, Lang D, Nadeau KC, Nowak-Wegrzyn A, Oppenheimer J, Perry T, Randolph C, Sicherer S, Simon R, Vickery B, and Wood R. Food Allergy: A practice parameter update-2014. J. of Allergy and Clinical Immunology. 2014 Aug. E publication. *Participated in design of parameters, material support, and review of data.
Manohar M and Nadeau KC. The Potential of anti-IgE in Food Allergy Therapy. Current Treatment Options in Allergy. 2014 Jun 1;1(2):145-156
Padula AM, Balmes JR, Eisen EA, Mann J, Noth EM, Lurmann FW, Pratt B, Tager IB, Nadeau K, Hammond SK. Ambient polycyclic aromatic hydrocarbons and pulmonary function in children. J Expo Sci Environ Epidemiol. 2014 Jun 18. *Participated in conception and design, enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
McKenzie RB, Berquist WE, Nadeau KC, Louie CY, Chen SF, Sibley RK, Glader BE, Wong WB, Hofmann LV, Esquivel CO, Cox KL. Novel protocol including liver biopsy to identify and treat CD8+ T-cell predominant acute hepatitis and liver failure. Pediatr Transplant. 2014 Jun 14. *Participated in conception and design, enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Begin P, Chinthrajah RS, Nadeau KC. Oral immunotherapy for the treatment of food allergy. Hum Vaccin Immunother. 2014 Jun 5;10(8).
Begin P and Nadeau KC. Epigenetic regulation of asthma and allergic disease. Allergy, Asthma, and Clinical Immunology. 2014 May 28;10 (1):27.
Otani IM, Bégin P, Kearney C, Dominguez TL, Mehrotra A, Bacal LR, Wilson S, Nadeau KC. Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects. Allergy Asthma Clin Immunol. 2014 May 12;10(1):25.
Jones PP, Nadeau KC. Introduction to the special issue on Stanford Immunology. Immunol Res. 2014 May;58(2-3):161-3.
Pellerin L, Jenks JA, Bégin P, Bacchetta R, Nadeau KC. Regulatory T cells and their roles in immune dysregulation and allergy. Immunol Res. 2014 May;58(2-3):358-68.
Klingbeil EC, Hew KM, Nygaard UC, Nadeau KC. Polycyclic aromatic hydrocarbons, tobacco smoke, and epigenetic remodeling in asthma. Immunol Res. 2014 May;58(2-3):369-73.
Bégin P, Dominguez T, Wilson SP, Bacal L, Mehrotra A, Kausch B, Trela A, Tavassoli M, Hoyte E, O'Riordan G, Blakemore A, Seki S, Hamilton RG, Nadeau KC. Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab. Allergy, Asthma, and Clinical Immunology. 2014 Feb 20;10(1):7.
Syed A, Garcia M, Kohli A, Maecker H, Tsai M, Galli S, and Nadeau KC. Peanut oral immunotherapy results in increased antigen-induced Treg function and hypomethylation of FOXP3. The Journal of Allergy and Clinical Immunology. 2014 Feb;133(2):500-10.
Kanai T, Jenks J, Seki S, Bacchetta R, and Nadeau KC. Identification of STAT5A and STAT5B Target Genes in Human T cells. PLoS One. 2014 Jan 30;9(1):e86790.
Bégin P, Winterroth LC, Dominguez T, Wilson SP, Bacal L, Mehrotra A, Kausch B, Trela A, Hoyte E, O'Riordan G, Seki S, Blakemore A, Woch M, Hamilton RG, Nadeau KC. Safety and feasibility of oral immunotherapy to multiple allergens for food allergy. Allergy, Asthma, and Clinical Immunology. 2014 Jan 15;10(1):1.

2013 Publications

Liu, J, Zhang, L, Winterroth, L, Garcia, M, Weiman, S, Wong, J, Sunwoo, J, and Nadeau, KC. Epigenetically-mediated pathogenic effects of phenanthrene on regulatory T cells. J Toxicol. 2013; 967-981.
Reber LL, Marichal T, Mukai K, Kita Y, Tokuoka SM, Roers A, Hartmann K, Karasuyama H, Nadeau KC, Tsai M, Galli SJ. Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice. J Allergy Clin Immunol. 2013 Oct;132(4):881-8. *Participated in obtaining funding, analysis and interpretation of data.
Syed A, Kohli A, and Nadeau KC. Food allergy diagnosis and therapy: where are we now? Immunotherapy. 2013 Sep; 5(9):931-44.
Chen R, Giliani S, Lanzi G, Mias GI, Lonardi S, Dobbs K, Manis J, Im H, Gallagher JE, Phanstiel DH, Euskirchen G, Lacroute P, Bettinger K, Moratto D, Weinacht K, Montin D, Gallo E, Mangili G, Porta F, Notarangelo LD, Pedretti S, Al-Herz W, Alfahdli W, Comeau AM, Traister RS, Pai SY, Carella G, Facchetti F, Nadeau KC, Snyder M, Notarangelo LD. Whole-exome sequencing identifies tetratricopeptide repeat domain 7A (TTC7A) mutations for combined immunodeficiency with intestinal atresias. J Allergy Clin Immunol. 2013 Sep;132(3):656-664. *Participated in acquisition of data, and analysis and interpretation of data.
Syed, A, Hew K, Kohli A, Knowlton G, Nadeau KC. Air Pollution and Epigenetics. Journal of Environmental Protection. 2013 Aug; 4:8A, 114-122.
Jenks JA, Seki S, Kanai T, Huang J, Morgan AA, Scalco RC, Nath R, Bucayu R, Wit JM, Al-Herz W, Ramadan D, Jorge AA, Bacchetta R, Hwa V, Rosenfeld R, Nadeau KC. Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells. Clin Immunol. 2013 Aug;148(2):227-36.
Dominguez TL, Bégin P, Nadeau KC. The use of epinephrine in acute allergic reaction to food. Pediatric Annals. 2013 Jul;42(7):293-5.
Bégin P, Nadeau KC. Diagnosis of food allergy. Pediatr Ann. 2013 Jun 1;42(6):102-9.
Iyengar SR, Hoyte EG, Loza A, Bonaccorso S, Chiang D, Umetsu DT, Nadeau KC. Immunologic effects of omalizumab in children with severe refractory atopic dermatitis: a randomized, placebo-controlled clinical trial. Int Arch Allergy Immunol. Jun 2013;162(1):89-93
Ma J, Strub P, Lavori PW, Buist AS, Camargo CA Jr, Nadeau KC, Wilson SR, Xiao L. DASH for asthma: A pilot study of the DASH diet in not-well-controlled adult asthma. Contemporary Clinical Trials. 2013 May 3. *Participated in acquisition of data, analysis and interpretation of data, technical, and material support.
Le-Carlson M, Seki S, Abarbanel D, Quiros A, Cox K, and Nadeau KC. Markers of antigen presentation and activation on eosinophils and T-cells in the esophageal tissue of patients with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):257-62.
Abarbanel DN, Seki SM, Davies Y, Marlen N, Benavides JA, Cox K, Nadeau KC, Cox KL. Immunomodulatory Effect of Vancomycin on Treg in Pediatric Inflammatory Bowel Disease and Primary Sclerosing Cholangitis. J Clin Immunol. 2013 Feb;33(2):397-406. *Participated in acquisition of data, analysis and interpretation of data, drafting of manuscript, critical revision of the manuscript for important intellectual content, technical support, material support, and statistical analysis.

2012 Publications

Runyon RS, Cachola LM, Rajeshuni N, Hunter T, Garcia M, Ahn R, Lurmann F, Krasnow R, Jack LM, Miller RL, Swan GE, Kohli A, Jacobson AC, and Nadeau KC. Asthma discordance in twins is linked to epigenetic modifications of T cells. PLoS One. 2012;7(11): p. 487-496.
Kanai T, Jenks J, Nadeau KC. The STAT5b pathway defect and Autoimmunity. Frontiers in Immunology. 2012; 3:234.
Kohli, A, Garcia, M, Miller, R, Maher, C, Humblet, O, Hammond, K, and Nadeau, KC. Secondhand smoke in combination with ambient air pollution exposure is associated with increased CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children. J. of Clinical Epigenetics. 2012 Sep 25;4(1):17. 2012.
Swamy RS, Reshamwala N, Hunter T, Vissamsetti S, Santos CB, Baroody FM, Hwang PH, Hoyte EG, Garcia MA, Nadeau KC. Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy. J Allergy Clin Immunol. 2012 Jul;130(1):215-224. (Recommended by Faculty 1000)
Yu GP, Weldon B, Neale-May S, Nadeau KC. The Safety of Peanut Oral Immunotherapy in Peanut-Allergic Subjects in a Single-Center Trial. Int Arch Allergy Immunol. 2012 Jun 1;159(2):179-182.
Gernez Y, Tirouvanziam R, Reshamwala N, Yu G, Weldon BC, Galli SJ, Herzenberg LA, Nadeau KC. Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients. J Clin Immunol. 2012 Jun;32(3):565-73.
Bedoret D, Singh AK, Shaw V, Hoyte EG, Hamilton R, DeKruyff RH, Schneider LC, Nadeau KC (co-senior author), Umetsu DT. Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab. Mucosal Immunol. 2012 May;5(3):267-76.
Morgan AA, Pyrgos VJ, Nadeau KC, Williamson PR, Butte AJ. Multiplex meta-analysis of RNA expression to identify genes with variants associated with immune dysfunction. J Am Med Inform Assoc. 2012 Mar-Apr;19(2):284-8. *Participated in enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Chen R, Miriami E, Karczewski KJ, Hariharan M, Dewey FE, Cheng Y, Clark MJ, Im H, Habegger L, Balasubramanian S, O'Huallachain M, Dudley JT, Hillenmeyer S, Haraksingh R, Sharon D, Euskirchen G, Lacroute P, Bettinger K, Boyle AP, Kasowski M, Grubert F, Seki S, Garcia M, Whirl-Carrillo M, Gallardo M, Blasco MA, Greenberg PL, Snyder P, Klein TE, Altman RB, Butte AJ, Ashley EA, Gerstein M, Nadeau KC, Tang H, Snyder M. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell. 2012 Mar 16;148(6):1293-307. *Participated in enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Recher M, Burns S, de la Fuente MA, Volpi S, Dahlberg C, Walter J, Moffitt K, Matthew D, Honke N, Lang, P, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau KC, Bouma G, Delmonte O, Frugoni F, Fomin A, Buchbinder D, Lundequist E-M, Massaad MJ, Tsokos G, Hartwig J, Manis J, Terhorst C, Geha R, Snapper S, Lang K, Malley R, Westerberg L, Thrasher A, Notarangelo L. B-cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22;119(12):2819-28. *Participated in enrolling patients in the study, and analysis and interpretation of data.
Pedroza L, Kumar V, Mace E, Nadeau KC, Perez E, Ruuskanen O, Orange J. AIRE contributes to Dectin-1-induced TNF-a production 1 and complexes with CARD9, Syk, and Dectin-1. J Allergy Clin Immunol. 2012 Feb;129(2):464-72. *Participated in enrolling patients in the study and analysis and interpretation of data.
Nadeau KC, Kohli A, Iyengar S, DeKruyff RH, Umetsu DT. Oral immunotherapy and anti-IgE antibody-adjunctive treatment for food allergy. Immunol Allergy Clin North Am. 2012 Feb;32(1):111-33.

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Our Pioneering Research

Our Center brings together top-ranked scientists, physician-scientists, clinical caregivers and specialists, as well as world-class research teams with the goals of making long lasting changes in the field of allergy research and developing a cure for allergies.

Laboratory Research

Computational Biology Research

Clinical Trials

Access to our groundbreaking research findings and tests are available to all sites and patients within our worldwide alliance.

We use our innovative measurement tools and scientific knowledge in immunology and genetics to discover the cause of allergies and develop strategies to prevent them.

Recent Peer-Reviewed Research Publications

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