Phosphorylation of alphaB-crystallin supports reactive astrogliosis in demyelination.
Kuipers HF, Yoon J, Van Horssen J, Han MH, Bollyky PL, Palmer TD, Steinman L.
Proc Natl Acad Sci USA. 2017 Feb 28;114(9):E1745-E1754. doi: 10.1073/pnas.1621314114. Epub 2017 Feb 14. PMID: 2819689.

Integrative proteomics, genomics, and translational immunology approaches reveal mutated forms of Proteolipid Protein 1 (PLP1) and mutant-specific immune response in multiple sclerosis.
Qendro V, Bugos GA, Lundgren DH, Glynn J, Han MH, Han DK.
Proteomics, 2017 Mar; 17(6). Doi:10.1002/pmic.201600322. PMID: 28191734

Exosomal proteome analysis of cerebrospinal fluid detects biosignatures of neuromyelitis optica and multiple sclerosis
Jingyun Lee, Kimberly Q. McKinney, Antonis J. Pavlopoulos, May H. Han, Su-Hyun Kim, Ho Jin Kim, Sunil Hwang
Clinica Chimica Acta 462 (2016) 118–126

Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation.
Tsai HC, Han MH.
Drugs. 2016 Jun 18. [Epub ahead of print] PMID: 27318702

Effects of sphingosine-1-phosphate receptor 1 phosphorylation in response to FTY720 during neuroinflammation.
Hsing-Chuan Tsai, Yingxiang Huang, Christopher S. Garris, Monica A. Moreno, Christina W. Griffin, and May H. Han
JCI Insight. 2016;1(9):e86462. doi:10.1172/jci.insight.86462.

Intravenous Transplantation of Mesenchymal Progenitors Distribute Solely to the Lungs and Improve Outcomes in Cervical Spinal Cord Injury.
White SV, Czisch CE, Han MH, Plant CD, Harvey AR, Plant GW.
Stem Cells. 2016 Mar 17. doi: 10.1002/stem.2364. [Epub ahead of print] PMID: 26989838

Acute and Chronic Management of Neuromyelitis Optica Spectrum Disorder.
Sherman E, Han MH.
Curr Treat Options Neurol. 2015 Nov;17(11):48. doi: 10.1007/s11940-015-0378-x. PMID: 26433388

Update on biomarkers in neuromyelitis optica.
Melamed E, Levy M, Waters PJ, Sato DK, Bennett JL, John GR, Hooper DC, Saiz A, Bar-Or A, Kim HJ, Pandit L, Leite MI, Asgari N, Kissani N, Hintzen R, Marignier R, Jarius S, Marcelletti J, Smith TJ, Yeaman MR, Han MH, Aktas O, Apiwattanakul M, Banwell B, Bichuetti D, Broadley S, Cabre P, Chitnis T, De Seze J, Fujihara K, Greenberg B, Hellwig K, Iorio R, Jarius S, Klawiter E, Kleiter I, Lana-Peixoto M, Nakashima, O'Connor K, Palace J, Paul F, Prayoonwiwat N, Ruprecht K, Stuve O, Tedder T, Tenembaum S, Garrahan JP, Aires B, van Herle K, van Pelt D, Villoslada P, Waubant E, Weinshenker B, Wingerchuk D, Würfel J, Zamvil S.
Neurol Neuroimmunol Neuroinflamm. 2015 Jul 23;2(4):e134. doi: 10.1212/NXI.0000000000000134. eCollection 2015 Aug. Review.
PMID:26236760

Patient experience and practice trends in multiple sclerosis - clinical utility of fingolimod.
Lee JM, Han MH.
Patient Prefer Adherence. 2015 May 21;9:685-93. doi: 10.2147/PPA.S57354. eCollection 2015. Review. PMID: 26056436

HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation.
Blaho VA, Galvani S, Engelbrecht E, Liu C, Swendeman SL, Kono M, Proia RL, Steinman L, Han MH, Hla T.
Nature. 2015 Jun 8. doi: 10.1038/nature14462. [Epub ahead of print] PMID: 26053123

Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.
Garris CS, Wu L, Acharya S, Arac A, Blaho VA, Huang Y, Moon BS, Axtell RC, Ho PP, Steinberg GK, Lewis DB, Sobel RA, Han DK, Steinman L, Snyder MP, Hla T, Han MH.
Nat Immunol. 2013 Nov;14(11):1166-72. doi: 10.1038/ni.2730. Epub 2013 Sep 29.
PMID: 24076635

Identification of naturally occurring Fatty acids of the myelin sheath that resolve neuroinflammation.
Ho PP, Kanter JL, Johnson AM, Srinagesh HK, Chang EJ, Purdy TM, van Haren K, Wikoff WR, Kind T, Khademi M, Matloff LY, Narayana S, Hur EM, Lindstrom TM, He Z, Fiehn O, Olsson T, Han X, Han MH, Steinman L, Robinson WH.
Sci Transl Med. 2012; 4 (137): 137ra73

Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.
Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini SE, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L.
J Exp Med. 2012

Protective effect of an elastase inhibitor in a neuromyelitis optica-like disease driven by a peptide of myelin oligodendroglial glycoprotein.
Herges K, de Jong BA, Kolkowitz I, Dunn C, Mandelbaum G, Ko RM, Maini A, Han MH, Killestein J, Polman C, Goodyear AL, Dunn J, Steinman L, Axtell RC.
Mult Scler. 2012

T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis.
Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, Naves R, Han M, Zhong F, Castellanos JG, Mair R, Christakos A, Kolkowitz I, Katz L, Killestein J, Polman CH, de Waal Malefyt R, Steinman L, Raman C.
Nat Med. 2010; 16 (4): 406-12

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.
Schulze-Topphoff U, Prat A, Prozorovski T, Siffrin V, Paterka M, Herz J, Bendix I, Ifergan I, Schadock I, Mori MA, Van Horssen J, Schröter F, Smorodchenko A, Han MH, Bader M, Steinman L, Aktas O, Zipp F.
Nat Med. 2009; 15 (7): 788-93

Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity.
Platten M, Youssef S, Hur EM, Ho PP, Han MH, Lanz TV, Phillips LK, Goldstein MJ, Bhat R, Raine CS, Sobel RA, Steinman L.
Proc Natl Acad Sci U S A. 2009; 106 (35): 14948-53

Systems biology for identification of molecular networks in multiple sclerosis.
Han MH, Steinman L.
Mult Scler. 2009; 15 (5): 529-30

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets.
Han MH, Hwang SI, Roy DB, Lundgren DH, Price JV, Ousman SS, Fernald GH, Gerlitz B, Robinson WH, Baranzini SE, Grinnell BW, Raine CS, Sobel RA, Han DK, Steinman L.
Nature. 2008; 451 (7182): 1076-81

Complete List of Publications