Selected Publications
Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport.
Liu JJ, Ding J, Wu C, Bhagavatula P, Cui B, Chu S, Mobley WC, Yang Y. Proc Natl Acad Sci U S A. 2007; 104 (7): 2223-8
Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport.
Ding J, Allen E, Wang W, Valle A, Wu C, Nardine T, Cui B, Yi J, Taylor A, Jeon NL, Chu S, So Y, Vogel H, Tolwani R, Mobley W, Yang Y. Hum Mol Genet. 2006; 15 (9): 1451-63
Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway.
Wang W, Ding J, Allen E, Zhu P, Zhang L, Vogel H, Yang Y. Curr Biol. 2005; 15 (22): 2050-5
Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival.
Allen E, Ding J, Wang W, Pramanik S, Chou J, Yau V, Yang Y. Nature. 2005; 438 (7065): 224-8
BPAG1n4 is essential for retrograde axonal transport in sensory neurons.
Liu JJ, Ding J, Kowal AS, Nardine T, Allen E, Delcroix JD, Wu C, Mobley W, Fuchs E, Yang Y. J Cell Biol. 2003; 163 (2): 223-9
Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin.
Ding J, Liu JJ, Kowal AS, Nardine T, Bhattacharya P, Lee A, Yang Y. J Cell Biol. 2002; 158 (3): 427-33
Crossroads on cytoskeletal highways.
Fuchs E, Yang Y. Cell. 1999; 98 (5): 547-50
An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments.
Yang Y, Dowling J, Yu QC, Kouklis P, Cleveland DW, Fuchs E. Cell. 1996; 86 (4): 655-65
A dysfunctional desmin mutation in a patient with severe generalized myopathy.
Muñoz-Mármol AM, Strasser G, Isamat M, Coulombe PA, Yang Y, Roca X, Vela E, Mate JL, Coll J, Fernández-Figueras MT, Navas-Palacios JJ, Ariza A, Fuchs E. Proc Natl Acad Sci U S A. 1998; 95 (19): 11312-7
Integrators of the cytoskeleton that stabilize microtubules.
Yang Y, Bauer C, Strasser G, Wollman R, Julien JP, Fuchs E. Cell. 1999; 98 (2): 229-38