Recent Publications
Jan E, Kinzy TG, Sarnow P. (2003) Divergent tRNA-like element supports initiation, elongation and termination of protein biosynthesis. Proc. Natl. Acad. Sci. USA 100: 15410-15415. [Link]
Sarnow P. (2003) Viral internal ribosome entry site (IRES) elements: novel ribosome-RNA complexes and roles in pathogenesis. J. Virol. 77: 2801-2806. [Link]
Thompson SR, Sarnow P. (2003) Enterovirus 71 contains a type I IRES element that functions when eukaryotic initiation factor eIF4G is cleaved. Virology 315: 259-266. [Link]
Bushell M, Stoneley M, Sarnow P., Willis AE. (2004) Translation inhibition during the induction of apoptosis: RNA or protein degradation. Biochem. Soc. Trans. 32: 606-610. [Link]
Graham KL, Gustin KE, Rivera C, Kuyumcu-Martinez NM, Choe SS, Lloyd RE, Sarnow P, Utz PJ. (2004) Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during Poliovirus infection. J. Virol. 78: 6313-6321.610. [Link]
Qin X, Sarnow P. (2004) Preferential translation of IRES-containing mRNAs during the mitotic cycle in mammalian cells. J. Biol. Chem. 279: 13721-13728. [Link]
Spahn CMT, Jan E, Mulder A, Grassucci A, Sarnow P, Frank J. (2004) Cryo-EM visualization of a viral internal ribosome entry site bound to human 40S and 80S ribosomes: the IRES functions as an RNA-based translation factor. Cell. 118: 465-475. [Link]
Cevallos RC, Sarnow P. (2005) Factor-independent assembly of elongation-competent ribosomes by an internal ribosome entry site located in an RNA virus that infects penaeid shrimp. J. Virol. 79: 677-683. [Link]
Cherry S, Doukas T, Armknecht S, Wang H, Sarnow P, Perrimon N. (2005) Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev. 19: 445-452. [Link]
Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarnow P. (2005) Modulation of Hepatitis C virus RNA abundance by a liver-specific microRNA. Science 309: 1577-1581. [Link]
Sarnow P, Cevallos RC, Jan E. (2005) Takeover of host ribosomes by divergent IRES elements. Biochem Soc Trans. 33: 1479-1482. [Link]
Bushell M, Stoneley M, Kong YW, Hamilton TL, Spriggs KA, Dobbyn HC, Qin X, Sarnow P, Willis AE. (2006) Polypyrimidine tract binding protein regulates IRES-mediated gene expression during apoptosis. Mol. Cell. 23: 401-412. [Link]
Doudna JA, Sarnow P. (2006) Translation initiation by viral internal ribosome enrty sites. In “Translational Control in Biology and Medicine”; Hershey J.W.H., Mathews M.B. and Sonenberg N., eds. CSH Press, NY. p297-318.
Gustin KE, Sarnow P. (2006) Positive-stranded RNA viruses and the nucleus. In “Viruses and the Nucleus”. Wiley and Sons. Hiscox, J.A. (editor). p161-184.
Jopling CL, Norman KL, Sarnow P. (2006) Positive and negative modulation of viral and cellular mRNAs by liver-specific microRNA miR-122. Cold Spring Harbor Symposia on Quantitative Biology, 71: 369-76. [Link]
Lancaster AM, Jan E, Sarnow P. (2006) Initiation factor-independent translation mediated by the hepatitis C virus internal ribosome entry site. RNA 12: 894-902. [Link]
Sarnow P, Jopling CL, Norman K, Schütz S, Wehner KA. (2006) MicroRNAs: Expression, avoidance and subversion by vertebrate viruses. Nat. Rev. Micro. 4: 651-659. [Link]
Schütz S, Sarnow P. (2006) Interaction of viruses with the mammalian RNA interference pathway. Virology 344: 151-157. [Link]
Wehner KA, Sarnow P. (2006) Regulation of mRNA molecules by microRNAs. In “Translational Control in Biology and Medicine”; Hershey J.W.H., Mathews M.B. and Sonenberg N., eds. CSH Press, NY. p297-318.
Almstead LL, Sarnow P. (2007) Inhibition of U snRNP assembly by a virus-encoded proteinase. Genes Dev. 21: 1086-1097. [Link]
Schütz S, Sarnow P. (2007) How viruses avoid stress. Cell Host Microbe. 2(5):284-285. [Link]
Elmén J, Lindow M, Schütz S, Lawrence M, Petri A, Lindholm M, Hedtjärn M, Frydenlund Hansen H, Berger U, Gullans S, Kearney P, Sarnow P, Straarup EM, Kauppinen S. (2008) Efficient and safe LNA-mediated microRNA silencing in non-human primates.Nature 452: 896-899. [Link]
Jopling CL, Schütz S, Sarnow P. (2008) Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome. Cell Host Microbe 4(1): 77-85. [Link]
Costa A, Jan E, Sarnow P, Schneider D. (2009) The Imd pathway is involved in antiviral immune responses in Drosophila. PLoS One. 4(10):e7436. [Link]
Ying L, Lau A, Alvira CM, West R, Cann GM, Zhou B, Kinnear C, Jan E, Sarnow P, Van de Rijn M, Rabinovitch M. (2009) LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor. J. Cell Sci. 122:1441-1451. [Link]
Gu S, Jin L, Zhang F, Sarnow P, Kay MA. (2009) Biological basis for restriction of microRNA targets to the 3' untranslated region in mammalian mRNAs. Nat. Struct. Mol. Biol . 16(2):144-150. [Link]
Cevallos RC, Sarnow P. (2010) Temperature protects insect cells from infection by cricket paralysis virus. J. Virol. 84(3):1652-1655. [Link]
Norman KL, Sarnow P. (2010) Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms. J. Virol. 84(1):666-670. [Link]
Wehner KA, Schütz S, Sarnow P. (2010) OGFOD1: A Novel Modulator of eIF2α Phosphorylation and the Cellular Response to Stress. Molec. Cell Biol. (In Press)