Washington (CNN) -- President Obama will sign a landmark $875 billion health care reform bill into law at the White House on Tuesday, according to two Democratic officials familiar with the planning.

The bill passed the House of Representatives late Sunday night. It was approved by the Senate in December.

A separate package of changes passed by the House on Sunday still needs to be approved by the Senate. The officials noted that the Senate cannot begin debate on the package before Obama signs the underlying bill into law.

Health care reform now faces Senate challenge

The bill passed in a 219-212 vote after more than a year of bitter partisan debate. All 178 Republicans opposed it, along with 34 Democrats.

How House members voted

The measure constitutes the biggest expansion of federal health care guarantees since Medicare and Medicaid were enacted more than four decades ago.

The overall $940 billion plan is projected to extend insurance coverage to roughly 32 million Americans who don't have it now. It represents a significant step toward the goal of universal coverage sought by every Democratic president since Harry Truman.

Was it all worth it for Obama?

Most Americans will now be required to have health insurance or pay a fine. Larger employers will be required to provide coverage or risk financial penalties. Total individual out-of-pocket expenses will be capped and insurers will be barred from denying coverage based on gender or pre-existing conditions.

The compromise package would add to the bill's total cost partly by expanding insurance subsidies for middle- and lower-income families. The measure would scale back the bill's taxes on expensive insurance plans.

Numerous House members insisted they would not vote for the Senate bill without a clear promise that senators would approve the changes.

"This is what change looks like," Obama said shortly after the votes. The passage of health care reform is "not a victory for any one party. ... It's a victory for the American people and it's a victory for common sense."

The president said successful reform proves Americans "are still a people capable of doing big things."

Secretary of State Hillary Clinton -- who tried and failed during her husband's presidential administration to bring about sweeping health care reform -- celebrated the passage of the bill.

"If you ever doubt the resolve of President Obama to stay with a job, look at what we got done for the United States last night when it came to passing quality affordable health care for everyone," Clinton said Monday.

iReport: Share your views on health care reform

The rare Sunday votes occurred after a long weekend of intense negotiations among the White House, House leaders and individual Congress members. Obama traveled to Capitol Hill on Saturday to make a last-minute plea to the House Democratic caucus. He spent much of the past week trying to personally persuade dozens of members to vote for the bill.

House Speaker Nancy Pelosi, D-California, worked with administration officials to defuse a potential rebellion among socially conservative Democrats concerned that the bill wouldn't do enough to prevent taxpayer-funded abortions.

She also brokered a last-minute deal among several Democrats worried about disparities in Medicare funding for individual states.

Republicans failed to stop the Democratic health care initiative, despite using virtually every weapon in their legislative arsenal. GOP leaders have repeatedly warned the plan will lead to a government takeover of America's private employer-based health care system.

They have also argued it will lead to higher premiums and taxes while imposing harsh Medicare cuts and doing little to control spiraling medical costs.

Pelosi and Boehner comment

Shortly before the House voted on the bill, Pelosi said health care reform was necessary to end insurance industry abuses and bring greater economic stability to most Americans.

Congress will be "making history, making progress and restoring the American dream" by passing reform, she said.

It's time to "complete the great unfinished business of our society," she said. Health care "is a right and not a privilege."

House Minority Leader John Boehner, R-Ohio, argued that Democratic leaders had betrayed the trust of the public by pushing ahead with a bill that lacks broad public support.

"We have failed to listen to America and we have failed to reflect the will of our constituents," he said. "And when we fail to reflect that will, we fail ourselves and we fail our country."

He also slammed what he characterized as a legislative process marked by a lack of transparency and accountability.

"Look at how this bill was written," he said, his voice steadily rising. "Can you say it was done openly? With transparency and accountability? Without backroom deals? ... Hell no, you can't!"

CBO: Bill will reduce the deficit

The $875 billion bill now headed to Obama's desk is projected to cut the federal deficit by $118 billion over the next 10 years, according to the nonpartisan Congressional Budget Office.

If the compromise plan clears the Senate, the bill's total cost will rise by $65 billion. Projected deficits, however, will be reduced by an additional $25 billion.

The plan, according to CBO projections, will cut budget deficits by more than $1 trillion in its second decade.

It will subsidize insurance for a family of four making up to about $88,000 annually, or 400 percent of the federal poverty level.

It also creates a series of health insurance exchanges designed to make it easier for small businesses, the self-employed and the unemployed to pool resources and purchase less expensive coverage.

The bill cuts projected Medicare spending by roughly $500 billion, in part through reductions in the Medicare Advantage program. Democratic leaders have promised the reductions will not affect service to Medicare recipients.

Highlights of what's in the bill

Cutting out the "Cornhusker kickback"

While passage of the Senate bill is a significant win for Democrats on a major party priority, Pelosi had to take a number of steps in recent weeks to placate House members unhappy with the measure.

A deeply unpopular special exemption for the state of Nebraska from all new Medicaid expenses -- known as the "Cornhusker kickback" -- would be eliminated under the compromise plan. The federal government will instead assist every state by picking up 100 percent of the costs of expanded Medicaid coverage between 2014 and 2016, and 90 percent starting in 2020.

The speaker also tried to sweeten the deal for some progressive members of her caucus partly by adding additional subsidies and a major student loan overhaul measure to the compromise plan.

The measure -- a priority for Obama -- would end the practice of having private banks offer student loans and would expand direct lending from the government.

Several fiscally conservative Democrats were reassured by the Congressional Budget Office's estimate of the bill's long-term effect on the federal deficit.

Executive order promised to limit abortion funds

A key group of anti-abortion Democrats, meanwhile, was assuaged by a last-minute promise of an executive order from Obama stating that the provisions in the health care bill comply with the 32-year-old Hyde Amendment, which sharply restricts federal funding for abortion.

Emotions exploded shortly after the vote, however, as one Republican shouted "baby killer" at Michigan Rep. Bart Stupak, a leader of anti-abortion Democrats involved in negotiations over Obama's order.

Who shouted 'baby killer' at Stupak?

Republicans are still fuming over Democrats' decision to use a legislative procedure called reconciliation that will allow the compromise measures to clear the Senate with a simple majority of 51 votes.

Senate Democrats lost their filibuster-proof 60-seat supermajority in January with the election of GOP Sen. Scott Brown of Massachusetts.

Republicans say that reconciliation, which is limited to provisions pertaining to the budget, was not meant to pass a sweeping overhaul measure such as the health care bill. Democrats point out that reconciliation was used to pass several major bills in recent years, including President George W. Bush's 2001 and 2003 tax cuts.

CNN's Ted Barrett, Dana Bash, Craig Broffman, Tom Cohen, Lisa Desjardins, Evan Glass, Ed Henry, Brianna Keilar, Alan Silverleib, Deirdre Walsh and Robert Yoon contributed to this report.