Temporal lobe epilepsy is common, frequently refractory to treatment, and devastating to those affected. Our long-term goal is to better understand the pathophysiological mechanisms of this disease so that rational and effective therapies can be developed. We use electrophysiological, molecular, and anatomical techniques to evaluate neuronal circuitry in normal and in epileptic brains.
Paul Buckmaster, DVM, PhD
Professor
(650) 498-4774
Edwards R335
(650) 498-6259 (fax)
Emily Abrams
Research Technician
Yui Yin-Chu
Research Technician
Khushdev Thind, PhD
Research Assistant
Ruth Yamawaki
Research Assistant
Figure 1. Aberrant mossy fiber sprouting was measured by drawing contours around the entire granule cell layer (g) + molecular layer (m) (magenta line) and the Timm-positive part (cyan line) (A). h, Hilus; CA3, CA3 pyramidal cell layer. B, Isolated outlines with Timm-positive contour filled. Areas were recorded, and the percentage of the entire granule cell layer + molecular layer that was Timm positive was calculated.
