Themistocles (Tim) Assimes

Publications

• A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
  Nikpay, M., Goel, A., Won, H.-H., Hall, L. M., Willenborg, C., & Farrall, M. (2015). A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. NATURE GENETICS, 47(10), 1121-?.
• Contemporary Considerations for Constructing a Genetic Risk Score: An Empirical Approach.
  Goldstein, B. A., Yang, L., Salfati, E., & Assimes, T. L. (2015). Contemporary Considerations for Constructing a Genetic Risk Score: An Empirical Approach. Genetic epidemiology, 39(6), 439-445.
• Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease
  Ghosh, S., Vivar, J., Nelson, C. P., Willenborg, C., Segre, A. V., & McPherson, R. (2015). Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 35(7), 1712-1722.
• Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. Sazonova, O., Zhao, Y., Nürnberg, S., Miller, C., Pjanic, M., & Quertermous, T. (2015). Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS genetics, 11(5).
  
• Susceptibility Loci for Clinical CAD and Subclinical Coronary Atherosclerosis Throughout the Life-Course. Salfati, E., Nandkeolyar, S., Fortmann, S. P., Sidney, S., Hlatky, M. A., & Assimes, T. L. (2015). Susceptibility Loci for Clinical CAD and Subclinical Coronary Atherosclerosis Throughout the Life-Course. Circulation. Cardiovascular genetics.
  
• Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease Crosby, J., Peloso, G. M., Auer, P. L., Crosslin, D. R., Stitziel, N. O., & Kathiresan, S. (2014). Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease. NEW ENGLAND JOURNAL OF MEDICINE, 371(1), 22-31.
  
• Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease. Mäkinen, V.-P., Civelek, M., Meng, Q., Zhang, B., Zhu, J., & Assimes, T. L. (2014). Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease. PLoS genetics, 10(7).
  
• Dissecting the causal genetic mechanisms of coronary heart disease. Miller, C. L., Assimes, T. L., Montgomery, S. B., & Quertermous, T. (2014). Dissecting the causal genetic mechanisms of coronary heart disease. Current atherosclerosis reports, 16(5), 406-?.
  
• Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example. Goldstein, B. A., Knowles, J. W., Salfati, E., Ioannidis, J. Pa., & Assimes, T. L. (2014). Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example. Frontiers in genetics, 5, 254-?.
  
• Genetics and Genomics for the Prevention and Treatment of Cardiovascular Disease: Update A Scientific Statement From the American Heart Association Ganesh, S. K., Arnett, D. K., Assimes, T. L., Basson, C. T., Chakravarti, A., & Waldman, S. A. (2013). Genetics and Genomics for the Prevention and Treatment of Cardiovascular Disease: Update A Scientific Statement From the American Heart Association. CIRCULATION, 128(25), 2813-2851.
  
• Large-scale association analysis identifies new risk loci for coronary artery disease. Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., & Samani, N. J. (2013). Large-scale association analysis identifies new risk loci for coronary artery disease. Nature genetics, 45(1), 25-33.
  
• Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus. Miller, C. L., Anderson, D. R., Kundu, R. K., Raiesdana, A., Nürnberg, S. T., & Quertermous, T. (2013). Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus. PLoS genetics, 9(7).
  
• Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease Schunkert, H., Koenig, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., & Samani, N. J. (2011). Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. NATURE GENETICS, 43(4), 333-U153.
  
• Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies Assimes, T. L., Holm, H., Kathiresan, S., Reilly, M. P., Thorleifsson, G., & Quertermous, T. (2010). Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(19), 1552-1563.
  
• The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. Winkler, T. W., Justice, A. E., Graff, M., Barata, L., Feitosa, M. F., & Loos, R. Jf. (2015). The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS genetics, 11(10).
  
• Effect of Common Genetic Variants of Growth Arrest-Specific 6 Gene on Insulin Resistance, Obesity and Type 2 Diabetes in an Asian Population. Hsieh, C. H., Chung, R. H., Lee, W. J., Lin, M. W., Chuang, L. M., & Yu, Y. W. Effect of Common Genetic Variants of Growth Arrest-Specific 6 Gene on Insulin Resistance, Obesity and Type 2 Diabetes in an Asian Population. PloS one, 10(8), e0135681.
  
• Detecting clinically meaningful biomarkers with repeated measurements: An illustration with electronic health records Goldstein, B. A., Assimes, T., Winkelmayer, W. C., & Hastie, T. (2015). Detecting clinically meaningful biomarkers with repeated measurements: An illustration with electronic health records. BIOMETRICS, 71(2), 478-486.
  
• Genetically Determined Height and Coronary Artery Disease Nelson, C. P., Hamby, S. E., Saleheen, D., Hopewell, J. C., Zeng, L., & Samani, N. J. (2015). Genetically Determined Height and Coronary Artery Disease. NEW ENGLAND JOURNAL OF MEDICINE, 372(17), 1608-1618.
  
• Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene Knowles, J. W., Xie, W., Zhang, Z., Chennemsetty, I., Assimes, T. L., & Quertermous, T. (2015). Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. JOURNAL OF CLINICAL INVESTIGATION, 125(4), 1739-1751.
  
• Dissecting the Roles of MicroRNAs in Coronary Heart Disease via Integrative Genomic Analyses Huan, T., Rong, J., Tanriverdi, K., Meng, Q., Bhattacharya, A., & Yang, X. (2015). Dissecting the Roles of MicroRNAs in Coronary Heart Disease via Integrative Genomic Analyses. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 35(4), 1011-1021.
  
• Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis Freitag, D. F., Butterworth, A. S., Willeit, P., Howson, J. Mm., Burgess, S., & Danesh, J. (2015). Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. LANCET DIABETES & ENDOCRINOLOGY, 3(4), 243-253.
  
• New genetic loci link adipose and insulin biology to body fat distribution. Shungin, D., Winkler, T. W., Croteau-Chonka, D. C., Ferreira, T., Locke, A. E., & Mohlke, K. L. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518(7538), 187-196.
  
• Genetic studies of body mass index yield new insights for obesity biology. Locke, A. E., Kahali, B., Berndt, S. I., Justice, A. E., Pers, T. H., & Speliotes, E. K. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518(7538), 197-206.
  
• Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Do, R., Stitziel, N. O., Won, H.-H., Jørgensen, A. B., Duga, S., & Kathiresan, S. (2015). Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature, 518(7537), 102-106.
  
• Leukocyte Telomere Length and Risks of Incident Coronary Heart Disease and Mortality in a Racially Diverse Population of Postmenopausal Women. Carty, C. L., Kooperberg, C., Liu, J., Herndon, M., Assimes, T., & Reiner, A. P. (2015). Leukocyte Telomere Length and Risks of Incident Coronary Heart Disease and Mortality in a Racially Diverse Population of Postmenopausal Women. Arteriosclerosis, thrombosis, and vascular biology.
  
• Lean body mass and risk of incident atrial fibrillation in post-menopausal women. Azarbal, F., Stefanick, M. L., Assimes, T. L., Manson, J. E., Bea, J. W., & Perez, M. V. (2015). Lean body mass and risk of incident atrial fibrillation in post-menopausal women. European heart journal.
  
• DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative. Levine, M. E., Hosgood, H. D., Chen, B., Absher, D., Assimes, T., & Horvath, S. (2015). DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative. Aging.
  
• Leveraging population admixture to characterize the heritability of complex traits Zaitlen, N., Pasaniuc, B., Sankararaman, S., Bhatia, G., Zhang, J., & Price, A. L. (2014). Leveraging population admixture to characterize the heritability of complex traits. NATURE GENETICS, 46(12), 1356-1362.
  
• Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease Stitziel, N. O., Won, H.-H., Morrison, A. C., Peloso, G. M., Do, R., & Kathiresan, S. (2014). Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease. NEW ENGLAND JOURNAL OF MEDICINE, 371(22), 2072-2082.
  
• Defining the role of common variation in the genomic and biological architecture of adult human height Wood, A. R., Esko, T., Yang, J., Vedantam, S., Pers, T. H., & Frayling, T. M. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. NATURE GENETICS, 46(11), 1173-1186.
  
• Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index Wen, W., Zheng, W., Okada, Y., Takeuchi, F., Tabara, Y., & Tanaka, T. (2014). Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. HUMAN MOLECULAR GENETICS, 23(20), 5492-5504.
  
• Study of exonic variation identifies incremental information regarding lipid-related and coronary heart disease genes. Assimes, T. L., & Quertermous, T. (2014). Study of exonic variation identifies incremental information regarding lipid-related and coronary heart disease genes. Circulation research, 115(5), 478-480.
  
• Obesity, physical activity, and their interaction in incident atrial fibrillation in postmenopausal women. Azarbal, F., Stefanick, M. L., Salmoirago-Blotcher, E., Manson, Ja. E., Albert, C. M., & Perez, M. V. (2014). Obesity, physical activity, and their interaction in incident atrial fibrillation in postmenopausal women. Journal of the American Heart Association, 3(4).
  
• Multiple nonglycemic genomic Loci are newly associated with blood level of glycated hemoglobin in East asians. Chen, P., Takeuchi, F., Lee, J.-Y., Li, H., Wu, J.-Y., & Tai, E.-S. (2014). Multiple nonglycemic genomic Loci are newly associated with blood level of glycated hemoglobin in East asians. Diabetes, 63(7), 2551-2562.
  
• Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity Dimas, A. S., Lagou, V., Barker, A., Knowles, J. W., Maegi, R., & Prokopenko, I. (2014). Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity. DIABETES, 63(6), 2158-2171.
  
• Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset. Gordon, A. S., Tabor, H. K., Johnson, A. D., Snively, B. M., Assimes, T. L., & Nickerson, D. A. (2014). Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset. Human molecular genetics, 23(8), 1957-1963.
  
• Clinical interpretation and implications of whole-genome sequencing. Dewey, F. E., Grove, M. E., Pan, C., Goldstein, B. A., Bernstein, J. A., & Quertermous, T. (2014). Clinical interpretation and implications of whole-genome sequencing. JAMA, 311(10), 1035-1045.
  
• Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. Miller, C. L., Haas, U., Diaz, R., Leeper, N. J., Kundu, R. K., & Sczakiel, G. (2014). Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. PLoS genetics, 10(3).
  
• Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol Lange, L. A., Hu, Y., Zhang, H., Xue, Cy., Schmidt, E. M., & Willer, C. J. (2014). Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol. AMERICAN JOURNAL OF HUMAN GENETICS, 94(2), 233-245.
  
• The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model Downing, K. P., Nead, K. T., Kojima, Y., Assimes, T., Maegdefessel, L., & Leeper, N. J. (2014). The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model. VASCULAR MEDICINE, 19(1), 3-8.
  
• Near-Term Prediction of Sudden Cardiac Death in Older Hemodialysis Patients Using Electronic Health Records Goldstein, B. A., Chang, T. I., Mitani, A. A., Assimes, T. L., & Winkelmayer, W. C. (2014). Near-Term Prediction of Sudden Cardiac Death in Older Hemodialysis Patients Using Electronic Health Records. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 9(1), 82-91.
  
• Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease A Genome-Wide Analysis of Common Variants Dichgans, M., Malik, R., Koenig, I. R., Rosand, J., Clarke, R., & Schunkert, H. (2014). Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease A Genome-Wide Analysis of Common Variants. STROKE, 45(1), 24-36.
  
• Insulin resistance: regression and clustering. Yoon, S., Assimes, T. L., Quertermous, T., Hsiao, C.-F., Chuang, L.-M., & Olshen, R. A. (2014). Insulin resistance: regression and clustering. PloS one, 9(6).
  
• Use of Medicare Data to Identify Coronary Heart Disease Outcomes in the Women's Health Initiative Hlatky, M. A., Ray, R. M., Burwen, D. R., Margolis, K. L., Johnson, K. C., & Stefanick, M. L. (2014). Use of Medicare Data to Identify Coronary Heart Disease Outcomes in the Women's Health Initiative. CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES, 7(1), 157-162.
  
• Trans-ethnic fine mapping identifies a novel independent locus at the 3 ' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population Kuo, J. Z., Sheu, W. H.-H., Assimes, T. L., Hung, Y.-J., Absher, D., & Chen, Y.-D. I. (2013). Trans-ethnic fine mapping identifies a novel independent locus at the 3 ' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population. DIABETOLOGIA, 56(12), 2619-2628.
  
• Common variants associated with plasma triglycerides and risk for coronary artery disease. Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., & Kathiresan, S. (2013). Common variants associated with plasma triglycerides and risk for coronary artery disease. Nature genetics, 45(11), 1345-1352.
  
• Discovery and refinement of loci associated with lipid levels. Willer, C. J., Schmidt, E. M., Sengupta, S., Peloso, G. M., Gustafsson, S., & Abecasis, G. R. (2013). Discovery and refinement of loci associated with lipid levels. Nature genetics, 45(11), 1274-1283.
  
• Imputation of coding variants in African Americans: better performance using data from the exome sequencing project Duan, Q., Liu, E. Y., Auer, P. L., Zhang, G., Lange, E. M., & Li, Y. (2013). Imputation of coding variants in African Americans: better performance using data from the exome sequencing project. BIOINFORMATICS, 29(21), 2744-2749.
  
• Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes Yaghootkar, H., Lamina, C., Scott, R. A., Dastani, Z., Hivert, M.-F., & Frayling, T. M. (2013). Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes. DIABETES, 62(10), 3589-3598.
  
• Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus Miller, C. L., Anderson, D. R., Kundu, R. K., Raiesdana, A., Nuernberg, S. T., & Quertermous, T. (2013). Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus. PLOS GENETICS, 9(7).
  
• The shared allelic architecture of adiponectin levels and coronary artery disease. Dastani, Z., Johnson, T., Kronenberg, F., Nelson, C. P., Assimes, T. L., & Richards, J. B. (2013). The shared allelic architecture of adiponectin levels and coronary artery disease. Atherosclerosis, 229(1), 145-148.
  
• A systems biology framework identifies molecular underpinnings of coronary heart disease. Huan, T., Zhang, B., Wang, Z., Joehanes, R., Zhu, J., & Levy, D. (2013). A systems biology framework identifies molecular underpinnings of coronary heart disease. Arteriosclerosis, thrombosis, and vascular biology, 33(6), 1427-1434.
  
• Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. Randall, J. C., Winkler, T. W., Kutalik, Z., Berndt, S. I., Jackson, A. U., & Heid, I. M. (2013). Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS genetics, 9(6).
  
• Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes Xie, W., Wood, A. R., Lyssenko, V., Weedon, M. N., Knowles, J. W., & Walker, M. (2013). Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes. DIABETES, 62(6), 2141-2150.
  
• Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B. Jjm., Peal, D. S., & Loos, R. Jf. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature genetics, 45(6), 621-631.
  
• Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Berndt, S. I., Gustafsson, S., Mägi, R., Ganna, A., Wheeler, E., & Ingelsson, E. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature genetics, 45(5), 501-512.
  
• Genetic predisposition to higher blood pressure increases coronary artery disease risk. Lieb, W., Jansen, H., Loley, C., Pencina, M. J., Nelson, C. P., & Stewart, A. Fr. (2013). Genetic predisposition to higher blood pressure increases coronary artery disease risk. Hypertension, 61(5), 995-1001.
  
• Measurement of insulin-mediated glucose uptake: Direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp Knowles, J. W., Assimes, T. L., Tsao, P. S., Natali, A., Mari, A., & Abbasi, F. (2013). Measurement of insulin-mediated glucose uptake: Direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp. METABOLISM-CLINICAL AND EXPERIMENTAL, 62(4), 548-553.
  
• Association Between the Chromosome 9p21 Locus and Angiographic Coronary Artery Disease Burden A Collaborative Meta-Analysis Chan, K., Patel, R. S., Newcombe, P., Nelson, C. P., Qasim, A., & Ye, S. (2013). Association Between the Chromosome 9p21 Locus and Angiographic Coronary Artery Disease Burden A Collaborative Meta-Analysis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 61(9), 957-970.
  
• Long-Term Use of Angiotensin Receptor Blockers and the Risk of Cancer Azoulay, L., Assimes, T. L., Yin, H., Bartels, D. B., Schiffrin, E. L., & Suissa, S. (2012). Long-Term Use of Angiotensin Receptor Blockers and the Risk of Cancer. PLOS ONE, 7(12).
  
• FTO genotype is associated with phenotypic variability of body mass index Yang, J., Loos, R. Jf., Powell, J. E., Medland, S. E., Speliotes, E. K., & Visscher, P. M. (2012). FTO genotype is associated with phenotypic variability of body mass index. NATURE, 490(7419), 267-?.
  
• Randomized Trial of Personal Genomics for Preventive Cardiology Design and Challenges Knowles, J. W., Assimes, T. L., Kiernan, M., Pavlovic, A., Goldstein, B. A., & Ioannidis, J. Pa. (2012). Randomized Trial of Personal Genomics for Preventive Cardiology Design and Challenges. CIRCULATION-CARDIOVASCULAR GENETICS, 5(3), 368-376.
  
• Genetic determinants of the ankle-brachial index: A meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium Wassel, C. L., Lamina, C., Nambi, V., Coassin, S., Mukamal, K. J., & Murabito, J. M. (2012). Genetic determinants of the ankle-brachial index: A meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium. ATHEROSCLEROSIS, 222(1), 138-147.
  
• PREDICTING ACUTE SUDDEN CARDIAC DEATH Goldstein, B., Winkelmayer, W., & Assimes, T. (2012). PREDICTING ACUTE SUDDEN CARDIAC DEATH. NEPHROLOGY DIALYSIS TRANSPLANTATION, 27, 59-59.
  
• Central obesity is important but not essential component of the metabolic syndrome for predicting diabetes mellitus in a hypertensive family-based cohort. Results from the Stanford Asia-pacific program for hypertension and insulin resistance (SAPPHIRe) Taiwan follow-up study Lee, I.-T., Chiu, Y.-F., Hwu, C.-M., He, C.-T., Chiang, F.-T., & Sheu, W. Hh. (2012). Central obesity is important but not essential component of the metabolic syndrome for predicting diabetes mellitus in a hypertensive family-based cohort. Results from the Stanford Asia-pacific program for hypertension and insulin resistance (SAPPHIRe) Taiwan follow-up study. CARDIOVASCULAR DIABETOLOGY, 11.
  
• Evaluation of the Metabochip Genotyping Array in African Americans and Implications for Fine Mapping of GWAS-Identified Loci: The PAGE Study Buyske, S., Wu, Y., Carty, C. L., Cheng, I., Assimes, T. L., & North, K. E. (2012). Evaluation of the Metabochip Genotyping Array in African Americans and Implications for Fine Mapping of GWAS-Identified Loci: The PAGE Study. PLOS ONE, 7(4).
  
• Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies Sarwar, N., Butterworth, A. S., Freitag, D. F., Gregson, J., Willeit, P., & Danesh, J. (2012). Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. LANCET, 379(9822), 1205-1213.
  
• A LARGE-SCALE MULTI ETHNIC STUDY OF A DIRECT MEASURE OF INSULIN SENSITIVITY DEMONSTRATES THAT SOUTH ASIANS ARE THE MOST INSULIN RESISTANT ETHNIC GROUP IN THE US Divakaruni, M. S., Abbasi, F., Desai, M., Lamendola, C., Palaniappan, L., & Assimes, T. (2012). A LARGE-SCALE MULTI ETHNIC STUDY OF A DIRECT MEASURE OF INSULIN SENSITIVITY DEMONSTRATES THAT SOUTH ASIANS ARE THE MOST INSULIN RESISTANT ETHNIC GROUP IN THE US. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13), E1792-E1792.
  
• Age-Related Somatic Structural Changes in the Nuclear Genome of Human Blood Cells Forsberg, L. A., Rasi, C., Razzaghian, H. R., Pakalapati, G., Waite, L., & Dumanski, J. P. (2012). Age-Related Somatic Structural Changes in the Nuclear Genome of Human Blood Cells. AMERICAN JOURNAL OF HUMAN GENETICS, 90(2), 217-228.
  
• Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias Clarke, R., Bennett, D. A., Parish, S., Verhoef, P., Dotsch-Klerk, M., & Peto, R. (2012). Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias. PLOS MEDICINE, 9(2).
  
• Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies Murabito, J. M., White, C. C., Kavousi, M., Sun, Y. V., Feitosa, M. F., & Kronenberg, F. (2012). Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies. CIRCULATION-CARDIOVASCULAR GENETICS, 5(1), 100-112.
  
• Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. Dastani, Z., Hivert, M.-F., Timpson, N., Perry, J. Rb., Yuan, X., & Kathiresan, S. (2012). Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS genetics, 8(3).
  
• Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1 Bown, M. J., Jones, G. T., Harrison, S. C., Wright, B. J., Bumpstead, S., & Samani, N. J. (2011). Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1. AMERICAN JOURNAL OF HUMAN GENETICS, 89(5), 619-627.
  
• Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk Ehret, G. B., Munroe, P. B., Rice, K. M., Bochud, M., Johnson, A. D., & Johnson, T. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. NATURE, 478(7367), 103-109.
  
• Immortal Person Time Bias in Pharmacoepidemiological Studies of Antihypertensive Drugs Assimes, T. L., & Suissa, S. (2011). Immortal Person Time Bias in Pharmacoepidemiological Studies of Antihypertensive Drugs. AMERICAN JOURNAL OF CARDIOLOGY, 108(6), 902-903.
  
• Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease Butterworth, A. S., Braund, P. S., Farrall, M., Hardwick, R. J., Saleheen, D., & Samani, N. J. (2011). Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease. PLOS GENETICS, 7(9).
  
• Human metabolic individuality in biomedical and pharmaceutical research Suhre, K., Shin, S.-Y., Petersen, A.-K., Mohney, R. P., Meredith, D., & Gieger, C. (2011). Human metabolic individuality in biomedical and pharmaceutical research. NATURE, 477(7362), 54-U60.
  
• Low lifetime recreational activity is a risk factor for peripheral arterial disease Wilson, A. M., Sadrzadeh-Rafie, A. H., Myers, J., Assimes, T., Nead, K. T., & Cooke, J. P. (2011). Low lifetime recreational activity is a risk factor for peripheral arterial disease. JOURNAL OF VASCULAR SURGERY, 54(2), 427-432.
  
• A Bivariate Genome-Wide Approach to Metabolic Syndrome STAMPEED Consortium Kraja, A. T., Vaidya, D., Pankow, J. S., Goodarzi, M. O., Assimes, T. L., & Borecki, I. B. (2011). A Bivariate Genome-Wide Approach to Metabolic Syndrome STAMPEED Consortium. DIABETES, 60(4), 1329-1339.
  
• Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits Speliotes, E. K., Yerges-Armstrong, L. M., Wu, J., Hernaez, R., Kim, L. J., & Borecki, I. B. (2011). Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits. PLOS GENETICS, 7(3).
  
• Family History of Heart Disease The Re-Emergence of a Traditional Risk Factor Assimes, T. L. (2011). Family History of Heart Disease The Re-Emergence of a Traditional Risk Factor. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(5), 628-629.
  
• Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies Reilly, M. P., Li, M., He, J., Ferguson, J. F., Stylianou, I. M., & Rader, D. J. (2011). Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. LANCET, 377(9763), 383-392.
  
• Sex differences in the prevalence of peripheral artery disease in patients undergoing coronary catheterization Rafie, A. Hs., Stefanick, M. L., Sims, S. T., Phan, T., Higgins, M., & Cooke, J. P. (2010). Sex differences in the prevalence of peripheral artery disease in patients undergoing coronary catheterization. VASCULAR MEDICINE, 15(6), 443-450.
  
• Genetics of Coronary Atherosclerotic Plaque Rupture and Myocardial Infarction Ferguson, J. F., Li, M., He, J., Qasim, A. N., Burnett, M. S., & Reilly, M. P. (2010). Genetics of Coronary Atherosclerotic Plaque Rupture and Myocardial Infarction. CIRCULATION, 122(21).
  
• Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., & Lindgren, C. M. (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. NATURE GENETICS, 42(11), 949-U160.
  
• Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., & Loos, R. Jf. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. NATURE GENETICS, 42(11), 937-U53.
  
• Hundreds of variants clustered in genomic loci and biological pathways affect human height Allen, H. L., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., & Hirschhorn, J. N. (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. NATURE, 467(7317), 832-838.
  
• Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study A Genome-Wide Association Meta-analysis Involving More Than 22 000 Cases and 60 000 Controls Preuss, M., Koenig, I. R., Thompson, J. R., Erdmann, J., Absher, D., & Schunkert, H. (2010). Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study A Genome-Wide Association Meta-analysis Involving More Than 22 000 Cases and 60 000 Controls. CIRCULATION-CARDIOVASCULAR GENETICS, 3(5), 475-U186.
  
• Call to Action: Cardiovascular Disease in Asian Americans A Science Advisory From the American Heart Association Palaniappan, L. P., Araneta, M. R. G., Assimes, T. L., Barrett-Connor, E. L., Carnethon, M. R., & Wong, N. D. (2010). Call to Action: Cardiovascular Disease in Asian Americans A Science Advisory From the American Heart Association. CIRCULATION, 122(12), 1242-1252.
  
• Biological, clinical and population relevance of 95 loci for blood lipids Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., & Kathiresan, S. (2010). Biological, clinical and population relevance of 95 loci for blood lipids. NATURE, 466(7307), 707-713.
  
• An "Almost Exhaustive" Search-Based Sequential Permutation Method for Detecting Epistasis in Disease Association Studies Ma, L., Assimes, T. L., Asadi, N. B., Iribarren, C., Quertermous, T., & Wong, W. H. (2010). An "Almost Exhaustive" Search-Based Sequential Permutation Method for Detecting Epistasis in Disease Association Studies. GENETIC EPIDEMIOLOGY, 34(5), 434-443.
  
• Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans Ingelsson, E., Langenberg, C., Hivert, M.-F., Prokopenko, I., Lyssenko, V., & Florez, J. C. (2010). Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans. DIABETES, 59(5), 1266-1275.
  
• Genome-wide meta-analyses identify multiple loci associated with smoking behavior Furberg, H., Kim, Y., Dackor, J., Boerwinkle, E., Franceschini, N., & Sullivan, P. F. (2010). Genome-wide meta-analyses identify multiple loci associated with smoking behavior. NATURE GENETICS, 42(5), 441-U134.
  
• Use of venlafaxine compared with other antidepressants and the risk of sudden cardiac death or near death: a nested case-control study Martinez, C., Assimes, T. L., Mines, D., Dell'Aniello, S., & Suissa, S. (2010). Use of venlafaxine compared with other antidepressants and the risk of sudden cardiac death or near death: a nested case-control study. BRITISH MEDICAL JOURNAL, 340.
  
• Age at incident treatment of hypertension and risk of cancer: a population study Assimes, T. L., & Suissa, S. (2009). Age at incident treatment of hypertension and risk of cancer: a population study. CANCER CAUSES & CONTROL, 20(10), 1811-1820.
  
• Characterizing the admixed African ancestry of African Americans Zakharia, F., Basu, A., Absher, D., Assimes, T. L., Go, A. S., & Tang, H. (2009). Characterizing the admixed African ancestry of African Americans. GENOME BIOLOGY, 10(12).
  
• Digital ischemia Kapoor, J. R., Kapoor, R., & Assimes, T. L. (2008). Digital ischemia. JOURNAL OF CARDIOVASCULAR MEDICINE, 9(12), 1285-1286.
  
• Long-term use of antihypertensive drugs and risk of cancer Assimes, T. L., Elstein, E., Langleben, A., & Suissa, S. (2008). Long-term use of antihypertensive drugs and risk of cancer. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 17(11), 1039-1049.
  
• Sax Differences In Peripheral Arterial Disease Rafie, A. Hs., Sims, T., Edwards, K. A., Phan, T., Stefanick, M. L., & Cooke, J. P. (2008). Sax Differences In Peripheral Arterial Disease. CIRCULATION, 118(18), S811-S811.
  
• Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study Assimes, T. L., Knowles, J. W., Basu, A., Iribarren, C., Southwick, A., & Quertermous, T. (2008). Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study. HUMAN MOLECULAR GENETICS, 17(15), 2320-2328.
  
• A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease Assimes, T. L., Knowles, J. W., Priest, J. R., Basu, A., Borchert, A., & Quertermous, T. (2008). A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. ATHEROSCLEROSIS, 198(1), 136-144.
  
• Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease Assimes, T. L., Knowles, J. W., Priest, J. R., Basu, A., Volcik, K. A., & Quertermous, T. (2008). Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease. HUMAN GENETICS, 123(4), 399-408.
  
• Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLRI) with CAD Knowles, J. W., Assimes, T. L., Boerwinkle, E., Fortmann, S. P., Go, A., & Quertermous, T. (2008). Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLRI) with CAD. BMC MEDICAL GENETICS, 9.
  
• Associations Among Multiple Markers and Complex Disease: Models, Algorithms, and Applications Assimes, T. L., Olshen, A. B., Narasimhan, B., & Olshen, R. A. (2008). Associations Among Multiple Markers and Complex Disease: Models, Algorithms, and Applications. GENETIC DISSECTION OF COMPLEX TRAITS, 2ND EDITION, 60, 437-464.
  
• Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease Hlatky, M. A., Quertermous, T., Boothroyd, D. B., Priest, J. R., Glassford, A. J., & Go, A. S. (2007). Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease. AMERICAN HEART JOURNAL, 154(6), 1035-1042.
  
• Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease Ardigo, D., Assimes, T. L., Fortmann, S. P., Go, A. S., Hlatky, M., & Quertermous, T. (2007). Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease. PHYSIOLOGICAL GENOMICS, 31(3), 402-409.
  
• Genetic susceptibility to peripheral arterial disease: A dark corner in vascular biology Knowles, J. W., Assimes, T. L., Li, J., Quertermous, T., & Cooke, J. P. (2007). Genetic susceptibility to peripheral arterial disease: A dark corner in vascular biology. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 27(10), 2068-2078.
  
• Heritability of left ventricular mass in Japanese families living in Hawaii: the SAPPHIRe Study Assimes, T. L., Narasimhan, B., Seto, T. B., Yoon, S., Curb, J. D., & Quertermous, T. (2007). Heritability of left ventricular mass in Japanese families living in Hawaii: the SAPPHIRe Study. JOURNAL OF HYPERTENSION, 25(5), 985-992.
  
• Does left ventricular mass differ between apparently normal adults of different ethnicities? The family blood pressure program Devereux, R. B., Cooper, R., Weder, A., Seto, T., Hanis, C., & Arnett, D. K. (2007). Does left ventricular mass differ between apparently normal adults of different ethnicities? The family blood pressure program. CIRCULATION, 115(8), E288-E288.
  
• Plasma asymmetric dimethylarginine is an independent marker of peripheral artery disease but not coronary artery disease: A novel marker of atherosclerosis with topographical specificity Ng, M. K., Assimes, T., Wang, B.- yin, McGee, S., Harada, R. K., & Cooke, J. P. (2006). Plasma asymmetric dimethylarginine is an independent marker of peripheral artery disease but not coronary artery disease: A novel marker of atherosclerosis with topographical specificity. CIRCULATION, 114(18), 775-776.
  
• Plasma asymmetric dimethylarginine is an independent marker for the presence and severity of peripheral artery disease Ng, M. K., Assimes, T., Wang, B. Y., McGee, S., Harada, R. K., & Cooke, J. P. (2006). Plasma asymmetric dimethylarginine is an independent marker for the presence and severity of peripheral artery disease. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 47(4), 294A-294A.
  
• Cardiac outcomes occurred more frequently with PCI than CABG or medical therapy in coronary artery disease. Assimes, T., & Hlatky, M. A. (2004). Cardiac outcomes occurred more frequently with PCI than CABG or medical therapy in coronary artery disease. ACP journal club, 141(3), 57-?.
  
• Inhaled corticosteroid use in asthma and the prevention of myocardial infarction Suissa, S., Assimes, T., Brassard, P., & Ernst, P. (2003). Inhaled corticosteroid use in asthma and the prevention of myocardial infarction. AMERICAN JOURNAL OF MEDICINE, 115(5), 377-381.
  
• Inhaled short acting beta agonist use in COPD and the risk of acute myocardial infarction Suissa, S., Assimes, T., & Ernst, P. (2003). Inhaled short acting beta agonist use in COPD and the risk of acute myocardial infarction. THORAX, 58(1), 43-46.
  
• The use of perioperative corticosteroids in craniomaxillofacial surgery Assimes, T. L., & Lessard, M. L. (1999). The use of perioperative corticosteroids in craniomaxillofacial surgery. PLASTIC AND RECONSTRUCTIVE SURGERY, 103(1), 313-321.
  
• Torsade de pointes with sotalol overdose treated successfully with lidocaine Assimes, T. L., & Malcolm, I. (1998). Torsade de pointes with sotalol overdose treated successfully with lidocaine. CANADIAN JOURNAL OF CARDIOLOGY, 14(5), 753-756.