Research
- Manuel Amieva, M.D., Ph.D.
- Ann M. Arvin, M.D.
- Sharon F. Chen, M.D.
- Cornelia L. Dekker, M.D.
- Hayley A. Gans, M.D.
- Kathleen Gutierrez, M.D.
- David K. Hong, M.D.
- David B. Lewis, M.D.
- Yvonne A. Maldonado, M.D.
- Philip A. Pizzo, M.D.
- Charles G. Prober, M.D.
Manuel Amieva, MD, PhD
Dr. Amieva studies the strategies pathogens utilize to colonize and subvert the epithelial barrier. He has focused on the epithelial junctions as a target for bacterial pathogens, since the cell-cell junctions serve as both a barrier to infection and also a major control site for epithelial function. In particular, his lab is interested in how the gastric pathogen Helicobater pylori may cause cancer by interfering with cell signaling at the epithelial junctions. They are also studying how various bacteria, such as Listeria monocytogenes, cross and invade the epithelium. <more...>
Ann M. Arvin, MD
Dr. Arvin’s research interests focus on the pathogenesis and host response to varicella zoster virus (VZV), with projects in three areas, including identification of viral proteins that are major targets of immunity, investigation of cell types associated with permissive and latent viral infection in vivo in humans and in the Scid-hu mouse, and generation of recombinant strains of VZV for analyses of alterations in pathogenicity. She is also Director of the Stanford University-LPCH Vaccine Program which is involved in development and evaluation of new pediatric vaccines.<more...>
Sharon F. Chen, MD
Dr. Chen is interested in cytomegalovirus (CMV) infections in immunocompromised hosts. She is currently studying the immune response to CMV virus in lung transplant recipients. <more...>
Cornelia L. Dekker, MD
Dr. Dekker is Medical Director of the Stanford-LPCH Vaccine Program. Her primary interest area is in vaccine clinical research with an emphasis on viral vaccines. She has studied the incidence and clinical course of congenital HCMV infection, serves as Stanford PI for the NIH-sponsored Vaccine and Treatment Evaluation Unit contract with Vanderbilt to test new vaccines, collaborates with Dr. Mark Davis on in-depth immunologic evaluation of response to influenza vaccines through the NIH-sponsored Stanford Cooperative Center for Translational Research on Human Immunology and Biodefense contract and is PI on a CDC contract to study safety of licensed vaccines in the Clinical Immunization Safety Assessment Network.<more...>
http://vaccines.stanford.edu/index.html
Hayley A. Gans, MD
Dr. Gans’ research involves delineating the ontogeny of human neonatal immune responses to viral antigens, using measles vaccine as a model antigen. She has conducted research defining T and B cell responses to measles immunization among young infants, and is further delineating the nature of these responses. <more...>
Kathleen Gutierrez, MD
Dr. Gutierrez’ research interests are in the areas of hospital and community epidemiology of pediatric infectious diseases. She is also the site principal investigator for the Collaborative Antiviral Study Group (CASG) studies of anti-viral therapies in infants with viral infections. <more...>
David K. Hong, MD
Dr. Hong's research interests involve the development of novel adjuvants for influenza vaccine. He is particularly interested in how vaccine adjuvants could increase the durability and immunogenicity of influenza vaccines. <more...>
David B. Lewis, M.D.
Dr. Lewis' research is focused on determining mechanisms limiting adaptive immunity, particularly that mediated by T cells, during early postnatal life. Studies in his laboratory are being carried out using circulating human T cells isolated from cord blood or peripheral blood, and using a number of murine models. <more...>
Yvonne A. Maldonado, M.D.
Dr. Maldonado’s research program is devoted to the epidemiologic aspects of viral infections in children. The four components of her program include:
- Molecular epidemiology of the immunogenicity and mutagenicity of oral poliovirus vaccine (OPV).
- Ontogeny of immune response to measles vaccine.
- Epidemiology of perinatal HIV infection.
- Clinical trials to prevent perinatal HIV infection. http://med.stanford.edu/maldonadoepigroup/
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Philip A. Pizzo, MD
Dr. Pizzo's research has focused on the management and prevention of infections in immunocompromised hosts - particularly in children with malignancy and children infected with HIV. He currently serves as the Dean of Stanford Medical School. <more...>
Charles G. Prober, M.D.
Dr. Prober’s research has focused on the epidemiology, immunology and therapy of herpes simplex type 2 (HSV-2) infections in pregnant women, their sexual partners and their neonates. He has also investigated the epidemiology of HSV-2 infection in adolescents. He is currently the Senior Associate Dean for Medical Education. <more...>
