Research at the Ludwig Center for Cancer Stem Cell Research and Medicine

The laboratories at the Ludwig Center are engaged in a wide variety of projects to uncover the secrets of cancer stem cells and find cancer therapies.

Laboratories:

Irving Weissman, MD
Michael Clark, MD
Philip Beachy, PhD

Ash Alizadeh, MD, PhD
Samuel Cheshier, MD, PhD
Matt van de Rijn, MD
Judith Shizuru, MD
Hiro Nakauchi, MD, PhD
Crystal Mackall, MD
Joanna Wysocka, PhD
Roeland Nusse, PhD
Maximilian Diehn, MD, PhD
Peter Kim, MD
Michelle Monje, MD, PhD

Projects:

• Myelodysplastic Syndrome
• Multiple Myeloma
• Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia, and Lymphoma
• Role of MicroRNAs in Normal and Malignant Hematopoiesis
• Bladder Cancer
• Brain Cancer
• Melanoma
• Epithelial Ovarian Cancer
• Identification of Cancer Stem Cells that Contain Low Levels of Reactive Oxygen Species and are Radioresistant
• DLL4 Blockade Inhibits Tumor Growth through Multiple Mechanisms Including a Reduction of Cancer Stem Cell Frequency
• Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells
• The Prognostic Role of a Gene Signature from Tumorigenic Breast Cancer Cells
• Dysregulated Gene Expression Networks in Human Acute Myelogenous Leukemia Stem CellsDiffuse Intrinsic Pontine Glioma (DIPG)
• Anti-Shh/anti-CD47 Combination Therapy in Bladder and Other Epithelial Cancers
• Inhibition of Hedgehog Signaling for Treatment of Chronic Myelogenous Leukemia (CML)
• Combined Use of Itraconazole and Arsenic Trioxide to Cause Regression of Hh-Dependent Tumors
  

Research Collaborations:

Ludwig Center scientists at Stanford are actively involved in collaborative research with other Ludwig Centers across the nation:

The Fred Hutchinson Cancer Research Center (Seattle)
Harvard Medical School (Boston)
Memorial Sloan-Kettering Cancer Center (New York)