Pediatric Neuro-Oncology Clinical Trials

Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients

Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 years

Phase II Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors (CNS GCT)

A Phase I/II Study of ABT-888 Poly(ADP-ribose) Polymerase Inhibitor, with Concurrent Radiation Therapy, in Children with Newly Diagnosed Diffuse Pontine Gliomas (DIPG)

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

Risk-Adapted Therapy for Children Less Than 3 Years of Age With Embryonal Brain Tumors, High-Grade Glioma, Choroid Plexus Carcinoma or Ependymoma

Molecular Stratification for Treatment of DIPG

Phase 2 Study of Alisterib as a single agent in Recurrent or Progressive Central Nervous System (CNS) Atypical Teratoid Rhabdoid Tumors (AT/RT) and Extra-CNS Malignant Rhabdoid Tumors (MRT) and in Combination Therapy in Newly Diagnoses AT/RT

Temozolomide with Irinotecan Versus Temozolomide, Irinotecan plus Bevacizumab for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG Randomized Phase II Screening Trial

A Phase II Randomized Trial of Lenalidomide (NSC # 703813, IND # 70116) in Pediatric Patients with Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytoma and Optic Pathway Gliomas

Phase I and Phase II of AZD6244 for Recurrent or Refractory Pediatric Low Grade Glioma

Phase II Study of Peginterferon alpha-2b (PEGIntron) for Pediatric Patients with Unresectable or Recurrent Craniopharyngiomas

Phase I study of CDK 4-6 inhibitor PD-0332991 in children with recurrent, progressive or refractory central nervous system tumors

 Phase 2 Study of Alisterib as a single agent in Recurrent or Progressive Central Nervous System (CNS) Atypical Teratoid Rhabdoid Tumors (AT/RT) and Extra-CNS Malignant Rhabdoid Tumors (MRT) and in Combination Therapy in Newly Diagnoses AT/RT

A Phase I Trial of Pomalidomide for children with recurrent, progressive or refractory CNS tumors

A Safety and Preliminary Efficacy trial of MK-3475 (pembrolizumab; anti-PD-1) in Children with recurrent, progressive or refractory high-grade gliomas (HGG) and DIPGs

Neuropsychological, Social, Emotional and Behavioral Outcomes in Children with Cancer

A Phase II Placebo-Controlled Trial of Modafinil to Improve Neurocognitive Deficits in Children Treated for a Primary Brain Tumor

Comprehensive Molecular Analysis of Tumor Samples Derived From Patients With Diffuse Brainstem Glioma - A Pilot Study (tissue only)

A Phase II Study of (18F) FLT for PET imaging of brain tumors in children

An analysis of PD1 pathway activity in malignant pediatric central nervous system (CNS) tumors