Neurobehavior

Neurobehavior

Animal models of human behavior, including disease models, and human behavioral testing.

Shared Facilities:

Stanford Behavioral and Functional Neuroscience Lab (SBFNL)

• Description —Stanford behavioral and functional neuroscience laboratory (SBFNL) will provide expertise in all aspects related to the design and implementation of behavioral experiments as well as data analysis and interpretation. The core is fully equipped to accommodate a full battery of behavioral tests relevant to learning and memory, sensory gating, place/fear conditioning, motor function, nociception, and anxiety-related behaviors. We are specialized in genetic and pharmacological phenotyping in both mouse and rat. In addition the center provides expertise in an array of acute and chronic experimental models of neurodegenerative disorders such as stroke and ischemic brain injury.
• Questions — Contact Mehrdad Shamloo, PhD  , (650) 725-3152
• Website — http://sbfnl.stanford.edu/
• Selected References

  Mouse model of Timothy syndrome recapitulates triad of autistic traits. PL Bader, M Faizi, SF Owen, MR Tadross, RW Alfa, GCL Bett, RW Tsien, RL Rasmusson, M Shamloo. PNAS (2011; in press). PubMedID: 21878566; PMCID: PMC3174658.

  Identification of a central role for complement in osteoarthritis. Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Larsen DM, Crish JF, Gurkan Bebek G, Ritter SY, Lindstrom TM, Hwang I, Wong HH, Punzi L, Encarnacion A, Shamloo M, Goodman SB, Wyss-Coray T, Goldring SR, Gobezie R, Crow MK, Holer VM, Lee DM, and Robinson WH, Nature Medicine (2011; in press). PubMedID: 22057346.

  Restoration of Norepinephrine-Modulated Contextual Memory in a Mouse Model of Down Syndrome. A Salehi, M Faizi, D Colas, J Valletta, J Laguna, R Takimoto-Kimura, A Kleschevnikov, SL Wagner, P Aisen, M Shamloo, and WC Mobley. Sci Transl Med 18 November 2009: Vol. 1, Issue 7, p. 7ra17. PubMedID: 20368182.

Stanford Cognitive and Systems Neuroscience Laboratory

• Description —The main goals of our research are to (1) discover fundamental principles underlying normal brain and cognitive development, (2) develop brain-based evidence and interventions to improve cognitive skills in children with learning disabilities, and (3) investigate atypical development of cognitive, affective and social information processing systems in children with autism. We use advanced brain imaging techniques (fMRI, sMRI, DTI and EEG) as well as behavioral, genetic and computational methods in our research. Populations currently under investigation include normal healthy children, adolescents and adults, children with learning disabilities and children with autism.
• Location — 1070 Arastradero Rd., Suite 220, Palo Alto
• Questions — Contact Us  , (650) 736-0128
• Website — http://stanford.edu/group/scsnl/cgi-bin/drupal_scsnl/
• Selected References

  Dynamic reconfiguration of structural and functional connectivity across core neurocognitive brain networks with development. Uddin L, Supekar K, Ryali S, Menon V. (2011). Journal of Neuroscience. 31(50), 18578-18589. PubMedID: 22171056.

  Differential electrophysiological response during rest, self-referential, and non-self-referential tasks in human posteromedial cortex. Dastjerdi M, Foster BL, Nasrullah S, Rauschecker AM, Dougherty RF, Townsend JD, Chang C, Greicius MD, Menon V, Kennedy DP, Parvizi J. (2011). Proc Natl Acad Sci U S A. 108(7), 3023-3038. PubMedID: 21282630; PMCID: PMC3041085.

  Decoding Temporal Structure in Music and Speech Relies on Shared Brain Resources but Elicits Different Fine-Scale Spatial Patterns. Abrams DA, Bhatara A, Ryali S, Balaban E, Levitin DJ & Menon V. (2011). Cerebral Cortex. 21(7), 1507-1518. PubMedID: 21071617; PMCID: PMC3116734