In 1935, Paul and Jean Hanna commissioned Frank Lloyd Wright to design their home to be built on the Stanford University campus. Construction, begun in 1937, continued in four stages over 25 years. The house was the first structure in the world to use Frank Lloyd Wright's hexagonal grid system, which has subsequently been used widely in American architecture.

The materials in the Hanna House Collection include correspondence, blueprints, drawings, photographs, and other records relating to the planning, design and construction of the campus home of Professor and Mrs. Paul R. Hanna. The collection focuses on the Hanna's work with architect Frank Lloyd Wright extending from the initial planning of the house through later renovations. Also included is a plaster star burst medallion, designed by Frank Lloyd Wright, from the proscenium arch of the Louis Sullivan designed Garrick Theater in the Schiller Building (1892) in Chicago.