Pediatric Neuro-Oncology Clinical Trials
New Diagnoses
ACNS0332
Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients
ACNS0831
Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 years
ACNS1123
Phase II Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors (CNS GCT)
SJMB12
A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
SJYC07
Risk-Adapted Therapy for Children Less Than 3 Years of Age With Embryonal Brain Tumors, High-Grade Glioma, Choroid Plexus Carcinoma or Ependymoma
DF DIPG
Molecular Stratification for Treatment of DIPG
SJATRT
Phase 2 Study of Alisterib as a single agent in Recurrent or Progressive Central Nervous System (CNS) Atypical Teratoid Rhabdoid Tumors (AT/RT) and Extra-CNS Malignant Rhabdoid Tumors (MRT) and in Combination Therapy in Newly Diagnoses AT/RT
Recurrent/Refractory Diseases
ACNS0821
Temozolomide with Irinotecan Versus Temozolomide, Irinotecan plus Bevacizumab for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG Randomized Phase II Screening Trial
ACNS1022
A Phase II Randomized Trial of Lenalidomide (NSC # 703813, IND # 70116) in Pediatric Patients with Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytoma and Optic Pathway Gliomas
SJATRT
Phase 2 Study of Alisterib as a single agent in Recurrent or Progressive Central Nervous System (CNS) Atypical Teratoid Rhabdoid Tumors (AT/RT) and Extra-CNS Malignant Rhabdoid Tumors (MRT) and in Combination Therapy in Newly Diagnoses AT/RT
PBTC-045
A Safety and Preliminary Efficacy trial of MK-3475 (pembrolizumab; anti-PD-1) in Children with recurrent, progressive or refractory high-grade gliomas (HGG) and DIPGs
Ancillary Studies
ALTE07C1
Neuropsychological, Social, Emotional and Behavioral Outcomes in Children with Cancer
ACCL0922
A Phase II Placebo-Controlled Trial of Modafinil to Improve Neurocognitive Deficits in Children Treated for a Primary Brain Tumor
NBTP02
Comprehensive Molecular Analysis of Tumor Samples Derived From Patients With Diffuse Brainstem Glioma - A Pilot Study (tissue only)
PBTC-N12
A Phase II Study of (18F) FLT for PET imaging of brain tumors in children
PBTC-N13
An analysis of PD1 pathway activity in malignant pediatric central nervous system (CNS) tumors
For more information
To find out the current status of any study please contact us at: Neuroonc@stanfordchildrens.org