Research Laboratories
The Alizadeh Lab
Directed by Dr. Ash Alizadeh
Our group's research is focused on attaining a better understanding of the initiation, maintenance, and progression of tumors, and their response to current therapies toward improving future treatment strategies.
The Chu Lab
Directed by Dr. Gilbert Chu
Our laboratory focuses on understanding how cells respond to DNA damage. To understand how DNA damaged by ultraviolet radiation is targeted for repair, we identified UV-damaged DNA binding activity (UV-DDB).
The Curtis Lab
Directed by Dr. Christina Curtis
The Curtis laboratory is focused on the development and application of innovative experimental, computational, and analytical approaches to improve the diagnosis, treatment, and early detection of cancer.
The Felsher Lab
Directed by Dr. Dean Felsher
Our laboratory investigates how oncogenes initiate and sustain tumorigenesis. We have developed model systems whereby we can conditionally activate oncogenes in normal human and mouse cells in tissue culture or in specific tissues of transgenic mice.
The Ford Lab
Directed by Dr. James Ford
The major investigative focus of this laboratory is to explore the mammalian genetic determinants of the inducible response and cellular sensitivity to DNA damaging cytotoxic agents, focusing particularly on the effects of the p53 and BRCA1 gene products on DNA repair and apoptosis.
The Ji Lab
Directed by Dr. Hanlee Ji
To improve the lives of individuals with cancer, we have embarked on a research initiative to use cutting edge genetics and technology to interrogate the fundamental genetic" digital" code responsible for cancer development and overall clinical behavior.
The R. Levy Lab
Directed by Dr. Ronald Levy
Our laboratory works at the boundry between immunology and cancer biology. We study normal lymphocyte biology and the biology of malignant lymphomas.
The S. Levy Lab
Directed by Dr. Shoshana Levy
Our research is aimed at understanding the mechanism of action of tetraspanins. This is a multi-gene family, which has shown remarkable conservation over evolution and whose members are expressed in mammals, insects and nematodes.
The Rohatgi Lab
Directed by Dr. Rajat Rohatgi
Cell-cell communication must be achieved with high fidelity to avoid catastrophes such as cancer. Our goal is to understand the detailed biochemical principles of cell-cell interactions, with an emphasis on how these biochemical reactions are organized in the spatial and temporal dimension. We strive to use our work to develop new diagnostics and therapeutics for human patients.
The Sikic Lab
Directed by Dr. Branimir I. Sikic
Our goals are to understand mechanisms of drug resistance in cancer cells and to develop more effective therapies. Current research ranges from biochemical and molecular studies in cellular models to Phase I, II and III clinical trials, and translational studies of molecular determinants of therapeutic response and toxicity.