Preclinical Imaging Instrumentation
Vevo 2100 Ultrasound
The Vevo® 2100 system expands the functionality, flexibility and image quality of the Vevo 770 system, operating at frequencies never before achieved with solid-state array transducers. The new MicroScan™ transducers provide increased frame rates, superb contrast, unrivaled resolution and a wider field of view. The system is easy to use, non-invasive and fast, providing extremely high throughput when needed.
Specifications*
- Superior resolution, 30 microns
- Uniform image quality through entire FOV
- Color and Power Doppler Modes for blood flow quantification & anatomical identification
- M-Mode single line acquisition allowing high-temporal resolution for LV functional analysis
- 3D-Mode Imaging & Volume Analysis
- Nonlinear Contrast Imaging
- Advanced measurements & quantification
Bruker Xtreme 4MP
The Bruker Xtreme 4MP is designed to provide high sensitivity luminescence and fluorescence imaging and high-resolution digital x-ray imaging. In addition, it has the capability of imaging radioisotopes with a high-speed phosphor screen. For bioluminescence and fluorescence imaging, the CCD camera of the 4MP is deeply cooled to -65°C resulting in a very low electronic noise (3e-). A large CCD detector (27.6 x 27.6 mm, 13.5 μm pixel size) coupled with a fast lens provides superior luminescence sensitivity (< 50 photons/sec/cm2/sr), which is very important for low light output applications.
Specifications*
- Camera Sensor Type Back-thinned, back-Illuminated 4MP
- CCD and Pixel Size 27.6 x 27.6 mm,13.5 μm
- CCD Tempreture -65 C Absolute typical
- Imaging Pixels 2048 x 2048
- Quantum efficiency >95% at 550 nm
- Field of View 7.2cm x 7.2cm min, 20cm x 20cm max
- Dark Current 0.004 e/s/pixel
- Min. Detectable Radiance <50 photons/s/sr/cm2
- Filter Slots 28 Excitation, 8 Emission
Genesys4 PET/X-Ray
G4 PET/X–RAY is a multimodality scanner that allows a quick scan for mice and rats with fully–integrated docking stations/imaging chambers and a painless acquisition/reconstruction software platform. G4 PET/X–Ray is the first system to break away from a conventional ring-based system by surrounding the animal (mouse full body and rat head/trunk) with four panel detectors, a novel system model, and iterative reconstruction. More detail description and system manuals can be found in Downloadable Specs.
Specifications*
Laser Repetition Rate Mass Range Mass Accuracy Resolution Resolution (broad mass range) MS, 200 and 400 Hz; MS/MS, 200, 400 and 1000 Hz 100 to 250,000 m/z (up to 1.2 MDa with COVALX HM2 Detector) < 10 ppm RMS with external calibration < 2.5 ppm RMS using internal calibration 30,000 for single peak in mass range 1200 to 3700 m/z > 16,000 for Angiotensin 1 > 18,000 for Glu1-Fib B > 25,000 for ACTH 1-17 and ACTH 18-39 > 18,000 for ACTH 7-38 *Provided by AB SCIEX (unpublished)
Computational Resources
The computer lab houses three workstations for general computational and data analysis. Currently available image/data analysis software packages include:
- Workstation 7 (Mac): OsiriX, ImageJ and Matalb
- Workstation 8 (PC): IRW(Inveon), Living Image, GE MicroView, Amide, Amira, ImageJ and Matlab.
- Workstation 9 (PC): IRW (Inveion), Living Image, GE MicroView, Amide, ImageJ and Matlab
